In vitro activity of N-formimidoyl thienamycin (MK 0787) compared with other beta-lactamase stable cephalosporins against beta-lactamase producing Staphylococcus aureus.
نویسندگان
چکیده
The in vitro activity of N-formimidoyl thienamycin (MK0787), a stable congener of thienamycin, was determined against 200 species of aerobic and 84 species of anaerobic bacteria. The compound was highly active against resistant gram-negative bacilli, penicillin-resistant Staphylococcus aureus, enterococci, and anaerobic bacteria. The new derivative of thienamycin was more active than the parent compound, probably reflecting the stability of the analog.
منابع مشابه
Comparison of in vitro activity of FCE 22101, a new penem, with those of other beta-lactam antibiotics.
The in vitro activity of FCE 22101, a new semisynthetic penem derivative, was compared with that of ceftriaxone, moxalactam, imipenem (formerly imipemide, N-formimidoyl thienamycin, or MK 0787), cefuroxime, ceftazidime, and other beta-lactams, when appropriate, against 472 recent isolates and known beta-lactam-resistant strains. The minimum inhibitory concentrations of FCE 22101 against 90% of ...
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متن کاملAntibacterial activities of a new stabilized thienamycin, N-formimidoyl thienamycin, in comparison with other antibiotics.
The in vitro activity of a new crystalline derivative of thienamycin, N-formimidoyl thienamycin (MK0787), was tested against 46 laboratory reference strains and 2,158 clinical isolates of gram-positive and -negative bacteria, including anaerobes, and compared with cefoxitin, cefaxolin, carbenicillin, and amikacin. MK0787 was significantly more active than the reference antibiotics against most ...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 18 4 شماره
صفحات -
تاریخ انتشار 1980